CT findings of Gaucher disease with large, calcified splenic masses mimicking tumors

A 26-year-old woman had large and calcified splenic masses of which the greatest lesion was subcapsular expansive, 17 cm sized one without intravenous contrast enhancement effect on computed tomographic images. The lesions were avascular masses on digital subtraction angiography. Histopathological examinations following a total splenectomy showed a proliferations of Gaucher cells alone with necrosis in the masses. Although such a case of Gaucher disease is quite rare, its importance lies in that it must be differentiated from the more common neoplastic disorders or abscess of the spleen.