Brain injury due to persistent hyperinsulinemic hypoglycemia of infancy

We report a case of brain damage in a 6-year old boy with seizures. On admission the patient presented with seizures two to three times a day since 1 year. Shortly after birth the boy was diagnosed with persistent hyperinsulinemic hypoglycemia of infancy. We describe the magnetic resonance imaging findings of brain lesions in our patient and correlate these to the literature. PHHI is a very uncommon disease although it is probably the most frequent cause of persistent neonatal hypoglycaemia. The disease is often associated with brain lesions, showing a rather typical distribution pattern, affecting most severely the parietal and occipital lobes of the cerebral hemispheres.