| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4229687 | European Journal of Radiology Open | 2014 | 8 Pages |
•An innovative sat-pulse based cine PC-MRI to investigate complex CSF dynamic.•Compared to conventional sequence and validated in the PPC of hydrocephalus patients.•No compromise neither on temporal nor on spatial resolution.•Compared to conventional exam: the PPC has same area but lower flow stroke volume.•It contributes to a better follow-up of patients with altered CSF circulation.
PurposesAccurate measurements of the cerebrospinal fluid that flows through the prepontine cistern (PPC) are challenging due to artefacts originating from basilar artery blood flow. We aim to accurately quantify cerebrospinal fluid (CSF) flow and stroke volume in the PPC, which is essential before endoscopic third ventriculostomy.Materials and methodsWe developed a new PC-MRI sequence prepared with Hadamard saturation bands to accurately quantify CSF flow in the PPC by suppressing the blood signal in the surrounding vessels. In total, 28 adult hydrocephalic patients (age 59 ± 20 years) were scanned using conventional PC-MRI and our developed sequence. CSF was separately extracted from the PPC and the foramen of Magendie, and flow (min and max) and stroke volume were quantified.ResultsOur modifications result in a complete deletion of signal from flowing blood, resulting in significantly reduced CSF stroke volume (Conv = 446 ± 113 mm3, Dev = 390 ± 119 mm3, p = 0.006) and flow, both minimum (Conv = −1630 ± 486 mm3/s, Dev = −1430 ± 406 mm3/s, p = 0.005) and maximum (Conv = 2384 ± 657 mm3/s, Dev = 1971 ± 62 mm3/s, p = 0.002) compared with the conventional sequence, whereas no change in the area of interest was noted (Conv = 236 ± 65 mm2, Dev = 249 ± 75 mm2, p = 0.21).ConclusionsAccurate and reproducible CSF flow and stroke volume measurements in the PPC can be achieved with sat-band prepared cine PC-MRI.
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