Transarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect

Article ID	Journal	Published Year	Pages	File Type
4237091	Journal of Vascular and Interventional Radiology	2016	7 Pages	PDF

Abstract

Transarterial chemoembolization using sorafenib resulted in a high intrahepatic concentration of sorafenib. The degree of tumor necrosis was significantly greater in the TAE-S group compared with the TAE-L group, but more severe toxicity of normal liver tissue also occurred.

Keywords

ALT HIF-1α HCC m/z AST Aspartate aminotransferase Alanine aminotransferase hypoxia-inducible factor 1α Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Mass-to-charge ratio Hepatocellular carcinoma

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Transarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect

Authors

Gyoung Min MD, Man Deuk MD, Do Young MD, Se Hoon MD, Jong Yun MD, Sung Il MD, Do Yun MD, Wonseon MD, Minwoo MD,