Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4237242 | Journal of Vascular and Interventional Radiology | 2015 | 9 Pages |
Abstract
Paclitaxel concentration in an atherosclerotic lesion model immediately after DEB angioplasty is nearly fourfold higher than in a healthy artery. Paclitaxel remains in the bloodstream longer when a universal state of fat arterial infiltration is achieved. These findings could have clinical implications, as studies testing commercial drug-eluting devices on healthy animals may be underestimating paclitaxel arterial uptake.
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Authors
RocÃo DVM, PhD, Alicia DVM, MD, PhD, Celia BSc, Fernando MD, PhD, Jose DVM, PhD, Ignacio DVM, PhD, Miguel A. MD, PhD,