Significant Prostacyclin/Thromboxane Level Imbalance after Lower Limb Arterial Angioplasty: A Possible Platelet Function Alteration

PGI2/TX balance homeostasis is of significant pathophysiologic importance. The authors found that PTA results in significant PGI2/TX imbalance and shifts more toward increased TX production. This finding is partly suggestive of significant platelet activation. This imbalance in PGI2/TX level may have implications for future failure of PTA. Future research in reducing this platelet activation is recommended.