| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4244474 | Médecine Nucléaire | 2010 | 8 Pages |
Abstract
Our prospective study of 40 cases shows the relevance of cardiac sympathetic postganglionic imaging with 123I-mIBG coupled with myocardial perfusion scintigraphy to discriminate between MSA and PD with a higher sensitivity (71.4%) compared to the test with L-DOPA but a lower specificity (78.9%) than the L-DOPA. The difficulty of diagnosis is firstly linked to damage occurring to both the pre- and postganglionic sympathetic systems in patients with MSA and secondly to the integrity of the sympathetic nerve endings in patients with PD. However, the association of data of scintigraphy with L-DOPA test show a significant improvement of sensibility (84%).
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Authors
N. Andriamisandratsoa, M. Anheim, C. Tranchant, D. Grucker, I.J. Namer,