Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4255805 | Transplantation Proceedings | 2013 | 6 Pages |
Abstract
Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight regulation of glucose leading to long-term complications. Recently, pancreatic islet transplantation to reconstitute insulin-producing β cells, has emerged as an alternative promising therapeutic approach. Unfortunately, the number of donor islets is too low compared with the high number of patients needing a transplantation leading to a search for renewable sources of high-quality β-cells. This review, summarizes more recent promising approaches to the generation of new β-cells from embryonic stem cells for transdifferentiation of adult cells, particularly a critical examination of the seminal work by Lumelsky et al.
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Authors
M.C. Gioviale, M. Bellavia, G. Damiano, A.I. Lo Monte,