| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4257553 | Transplantation Proceedings | 2012 | 4 Pages |
Abstract
ObjectiveThe objective of this study was to investigate the distribution of α-galactosyl (α-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue.MethodsDistribution of α-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry.Resultsα-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells.Conclusionα-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.
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Authors
W. Feng, L. Fu, J. Liu, D. Li,