THE RUBY ANNIVERSARY: Forty Years of Publication of Transplantation Proceedings—The First Decade: The Flowering of Immunology and Immunogenetics

The fortieth—ruby—anniversary of publication of Transplantation Proceedings chronicles the major developments in this field of expanding scientific and clinical importance. The first decade of publication included seminal findings in immunogenetics of the major histocompatibility complex—HLA-A, -B, -C, and -D—and immunology of induction and expression of alloimmunity from single cell to mammalian organisms. Initial dissections of destructive versus acceptance mechanisms toward allografts revealed cytotoxic versus suppressive/enhancing cell-mediates and humoral vectors. Initial clinical successes revealed technical accomplishments that warranted broader application of this technology as described in the second decade of the Proceedings—the advent of cyclosporine.