Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4260247 | Transplantation Proceedings | 2010 | 5 Pages |
Abstract
Non-melanoma skin cancers (NMSCs) are the most common malignancies after solid organ transplantation. Their incidence increases with time after transplantation. Calcineurin-inhibitors (CNIs) and azathioprine are known as skin neoplasia-initiating and -enhancing immunosuppressants. In contrast, increasing clinical experience suggests a relevant antiproliferative effect of mammalian target of rapamycin inhibitors, also named proliferation signal inhibitors (PSIs). We report the case of a cardiac allograft recipient with an impressive and consolidated reduction of recurrent NMSC, observed after conversion from CNI-therapy to a PSI-based protocol.
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Authors
J. Signorell, T. Hunziker, M. Martinelli, S.C. Koestner, P.J. Mohacsi,