| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4261600 | Transplantation Proceedings | 2009 | 4 Pages |
Many studies have shown a trend to improved long-term survival of renal transplant recipients. We analyzed the survival of recipients in Andalusia, Spain, from 1984–2007. The study included all the deceased donor, non-multiorgan grafts (n = 5599), grouped over successive 6-year periods, compared for corrected recipient survival. Changes were noted in the recipient characteristics: increased age, diabetes, vascular nephropathy, retransplantation, duration of prior replacement therapy, and reduction in positive hepatitis C virus (HCV+) serology. The univariate analysis showed a significantly worse survival associated with increased age (P < .001), diabetes (P < .001), HCV+ serology (P < .01; 1996–2007), and longer times on replacement therapy, but not with sex or retransplantation. The respective survivals at 1, 5, and 10 years in 1984–1989 were 93%, 86%, and 75%; in 1990–1995, 97%, 92%, and 84%; in 1996–2001, 96%, 91%, and 84%; and in 2002–2007, 96% and 92%, respectively. There was a significant improvement between the first and second periods (P < .001), but no change thereafter. The multivariate analysis (Cox) showed, a significant influence of age >40 years, female gender (relative risk [RR] 0.8; 95% confidence interval [CI] 0.7–0.9), diabetes (RR 2.5; 95% CI 1.8–3.4), and duration of prior replacement therapy (RR 1.08; 95% CI 1.05–1.1). The risk varied significantly depending on the period: using 2002–2007 as the reference period, the RR in 1984–1989 was 3.4 (95% CI 2.6–4.5); in 1990–1995, 1.8 (95% CI 1.3–2.3); and in 1996–2001, 1.4 (95% CI 1.1–1.8; all P < .02). The model remained for 1996–2007, though HCV+ serology was not significant. In conclusion, we showed a significant improvement in recipient survival in Andalusia over time. Correction for worse recipient characteristics suggests continued advances.
