Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4262714 | Transplantation Proceedings | 2007 | 4 Pages |
Abstract
Isolated liver perfusion has been used to evaluate the beneficial effects of several agents. In the present study, we developed a model using a recipient rat to reperfuse harvested livers in an ex situ, in vivo recirculating system. A total of 25 reperfusion procedures using adult male Wistar rats as donors and recipients were done. The preservation of the livers was performed with University of Wisconsin solution for 6 hours. Thereafter, the liver was reperfused with blood from another rat. We believe that the model presented herein offers an alternative method to evaluate early hepatocellular damage or hepatic microcirculation.
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Authors
C.R. Pinto Kruel, R. Scherer de Fraga, S. Dal Molin, S.M. Mota, G. Gasperin, C.T.S. Cerski, J.R. de Oliveira, M.R. Álvares-da-Silva,