Endothelin A (ETA) Receptors Are Involved in Augmented Adrenergic Vasoconstriction and Blunted Nitric Oxide-Mediated Relaxation of Penile Arteries from Insulin-Resistant Obese Zucker Rats

ET-1 enhances adrenergic vasoconstriction through presynaptic ETA receptors and antagonizes neural NO-mediated relaxation through postsynaptic smooth muscle ETA receptors in penile arteries from OZRs, which likely contributes to the augmented vasoconstriction and blunted nitrergic relaxation of erectile tissue under conditions of insulin resistance. Sánchez A, Contreras C, Martínez P, Muñoz M, Martínez AC, García-Sacristán A, Hernández M, and Prieto D. Endothelin (ETA) receptors are involved in augmented adrenergic vasoconstriction and blunted nitric oxide-mediated relaxation of penile arteries from insulin-resistant obese Zucker rats. J Sex Med 2014;11:1463-1474.