NO‐Donating Oximes Relax Corpora Cavernosa Through Mechanisms Other than Those Involved in Arterial Relaxation

This study shows for the first time that NO‐donating oximes relax mice CC. Therefore, oximes are a new group of molecules with potential for the treatment of ED. However, the underlying mechanism(s) of the FAL‐/FAM‐induced corporal relaxation clearly differ(s) from the one(s) involved in arterial vasorelaxation. Pauwels B, Boydens C, Decaluwé K, and Van de Voorde J. NO‐donating oximes relax corpora cavernosa through mechanisms other than those involved in arterial relaxation. J Sex Med 2014;11:1664-1674.