Expression of the Apelin-APJ Pathway and Effects on Erectile Function in a Mouse Model of Vasculogenic Erectile Dysfunction

These findings suggest that apelin-APJ signaling is a potential therapeutic target in the treatment of vasculogenic ED. Further studies are needed to develop a potent agonist for APJ and to determine the role of repeated dosing of apelin on long‐term recovery of erectile function. Kwon M‐H, Tuvshintur B, Kim WJ, Jin H‐R, Yin GN, Song K‐M, Choi MJ, Kwon K‐D, Batbold D, Ryu J‐K, and Suh J‐K. Expression of the apelin-APJ pathway and effects on erectile function in a mouse model of vasculogenic erectile dysfunction. J Sex Med 2013;10:2928-2941.