Powerful Relaxation of Phosphodiesterase Type 4 Inhibitor Rolipram in the Pig and Human Bladder Neck

PDE4 is present in the pig and human bladder neck smooth muscle, where rolipram exerts a much more potent relaxation than that elicited by PDE5 inhibitors. In pig, rolipram‐induced response is produced through the PKA pathway involving BKCa and IKCa channel activation and [Ca2+]idesensitization‐dependent mechanisms, this relaxation also being due to neuronal NO and H2S release. Ribeiro ASF, Fernandes VS, Martínez‐Sáenz A, Martínez P, Barahona MV, Orensanz LM, Blaha I, Serrano‐Margüello D, Bustamante S, Carballido J, García‐Sacristán A, Prieto D, and Hernández M. Powerful relaxation of phosphodiesterase type 4 inhibitor rolipram in the pig and human bladder neck. J Sex Med 2014;11:930-941.