Biphenyl-based phosphine: A well-defined, air-stable, and efficient ligand for the Mizoroki–Heck reaction

An efficient and stereoselective catalytic system has been reported for the Mizoroki–Heck cross coupling using a moderately bulky and electron-rich biphenyl-based phosphine, P(o-C6H4C6H4Me)Ph2 and a low Pd(OAc)2 loading. It is found that the nature of olefin has more beneficial effect on the reaction times and yields than the aryl halide which may be due to more contribution of the coordination and/or insertion of the olefin in the rate-determining step of the Heck reaction.

Graphical abstractCatalytic activity of a biphenyl-based phosphine, P(o-C6H4C6H4Me)Ph2, has been studied in the Heck reaction of various aryl bromides. The result showed that the nature of olefin has more beneficial effect on the reaction yields than the aryl halide which may be due to more contribution of the coordination and/or insertion of the olefin in the rate-determining step.Figure optionsDownload full-size imageDownload as PowerPoint slide