Impaired Endothelin Calcium Signaling Coupled to Endothelin Type B Receptors in Penile Arteries from Insulin-Resistant Obese Zucker Rats

Penile arteries from OZR exhibit an impaired ET-1 Ca2+ signaling along with changes in the ET receptor profile. Thus, whereas ET-1 contraction and the associated [Ca2+]i increase are mediated by smooth muscle ETA receptors in healthy arteries, ETB receptors contribute to contraction and are coupled to the augmented ET-1 [Ca2+]i response under conditions of insulin resistance. Contreras C, Sánchez A, Martínez P, Climent B, Benedito S, García-Sacristán A, Hernández M, and Prieto D. Impaired endothelin calcium signaling coupled to endothelin type B receptors in penile arteries from insulin-resistant obese Zucker rats. J Sex Med 2013;10:2141-2153.