The Effects of Anti‐TNF‐α Antibody on Hyperprolactinemia‐Related Suppression of hCG‐Induced Testosterone Release in Male Rats

The data support the hypothesis that the suppression of hCG‐induced T release associated with hyperPRL is through a TNF‐α‐mediated mechanism to suppress the Leydig cells. The effect of anti‐TNF‐α Ab is durable for at least 7 days. Besides intra‐testicular injection, there might be other ways available for administrating Ab. Anti‐TNF‐α Ab has a potential therapeutic application on hyperPRL‐induced hypogonadism or suppression of hCG‐induced T release. Huang WJS, Yang L‐Y, Pu H‐F, Tsai Y‐T, and Wang PS. The effects of anti‐TNF‐α antibody on hyperprolactinemia‐related suppression of hCG‐induced testosterone release in male rats. J Sex Med 2012;9:1005-1014.