Persistent Genital Arousal Disorder: Successful Treatment with Duloxetine and Pregabalin in Two Cases

ABSTRACTIntroductionPersistent genital arousal disorder (PGAD) is a rare condition in women that causes a lot of suffering. The pathophysiology is not well understood and an approach promising effective treatment has not been established so far.AimThis study aims to make colleagues aware of two treatment options, which proved to be successful in one case each and which might be worth further investigation.Main Outcome MeasuresSubjective distress from unwanted sexual arousal, unwanted orgasms, and pain in the genital area.MethodsTreatment of two women—36 and 41 years old—suffering from PGAD with duloxetine and pregabalin, respectively.ResultsIn both women, the treatment proved to be very successful over a long period of time. One of them experienced full remission (duloxetine) and the other one experienced substantial improvement (pregabalin), over a period now lasting for more than a year.ConclusionPregabalin and duloxetine, in particular, should be further investigated as possible medication for the treatment of PGAD. Philippsohn S and Kruger THC. Persistent genital arousal disorder: Successful treatment with duloxetine and pregabalin in two cases. J Sex Med 2012;9:213–217.