Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles

The results indicate that cyclic AMP‐ and cyclic GMP‐PDE isoenzymes are involved in the control of secretory activity and efferent neurotransmission in the SV. These findings might be of importance with regard to the identification of new therapeutic avenues to treat premature ejaculation. Ückert S, Waldkirch ES, Sonnenberg JE, Sandner P, Kuczyk MA, and Hedlund P. Expression and distribution of phosphodiesterase (PDE) isoenzymes in the human seminal vesicles. J Sex Med 2011;8:3058-3065.