Endothelin-1 Induces Contraction of Female Rat Internal Pudendal and Clitoral Arteries through ETA Receptor and Rho-Kinase Activation

We observed that the IPA and CA are sensitive to ET-1, signaling through the ETAR and Rho-kinase pathway. These data indicate that ET-1 may play a role in vaginal and clitoral blood flow and may be important in pathologies where ET-1 levels are elevated. Allahdadi KJ, Hannan JL, Tostes RC, and Webb RC. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ETA receptor and Rho-kinase activation.