Clinical Trial Methodology in Premature Ejaculation Observational, Interventional, and Treatment Preference Studies-Part I-Defining and Selecting the Study Population

These constructs can be incorporated into a multidimensional evidence‐based definition of PE and/or single‐item questions or multi‐item diagnostic questionnaires. The International Society of Sexual Medicine definition of PE reflects the contemporary understanding of PE, represents the state‐of‐the‐art multidimensional definition of PE, and is recommended as the basis of diagnosis of PE for all PE clinical trials. McMahon CG. Interventional and treatment preference studies-Part I-Defining and selecting the study population. J Sex Med 2008;5:1805-1816.