Guilt by Association: A Historical Perspective on Huggins, Testosterone Therapy, and Prostate Cancer

The fear that higher T will increase PCa growth stems from a theory of T‐dependent PCa growth that originated with observations in a special population (castrated men) that is not particularly relevant to T therapy in hypogonadal men. The negative view of T with regard to PCa should be recognized for what it is-guilt by association. Morgentaler A. Guilt by association: A historical perspective on Huggins, testosterone therapy, and prostate cancer. J Sex Med 2008;5:1834-1840.