Etiology of Ejaculation and Pathophysiology of Premature Ejaculation

The pathophysiology of both lifelong and acquired PE appears to be both neurobiogenic and psychogenic. While psychogenic factors appear to be contributory to PE, pharmacologic intervention of PE can modify intravaginal ejaculatory latency time (IELT), which suggests that IELT is a biological variable, and is likely biologically dependent upon neurotransmitters and hormones. Donatucci CF. Etiology of ejaculation and pathophysiology of premature ejaculation.