Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4273618 | The Journal of Sexual Medicine | 2006 | 8 Pages |
Abstract
Potentiation of the nitric oxide (NO) pathway by vardenafil improves vascular sexual responses in female rabbits and overcomes the inhibitory effects of acutely administered antidepressants on GVR, irrespective of the underlying pathophysiologic mechanism, i.e., disruption of the NO pathway or enhancement of αâadrenergic mechanisms. PDE5 inhibition may represent a reasonable approach to treat SRIâ or SRNIâinduced female sexual dysfunction, in particular, arousal disorders. Angulo J, Cuevas P, Cuevas B, Bischoff E, and Saenz de Tejada I. Antidepressantâinduced inhibition of genital vascular responses is reversed by vardenafil in female rabbits. J Sex Med 2006;3:988-995.
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Authors
Javier PhD, Pedro MD, PhD, Begona BSc, Erwin PhD, Iñigo Saenz MD,