Chronic Administration of an Oral Rho Kinase Inhibitor Prevents the Development of Vasculogenic Erectile Dysfunction in a Rat Model

These results indicate that the Rho/Rho kinase pathway is substantially involved in the development of erectile dysfunction and pelvic atherosclerosis, both of which could be prevented by chronic treatment with fasudil. Thus, Rho kinase might be considered a novel target for the prevention of vasculogenic erectile dysfunction. Park K, Kim SW, Rhu KS, and Paick J‐S. Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model. J Sex Med 2006;3:996-1003.