Prospective Correlation between Likelihood of Favorable Pathology on the 17-Gene Genomic Prostate Score and Actual Pathological Outcomes at Radical Prostatectomy

NCCN low risk patients had the most meaningful information provided by the Genomic Prostate Score. Men with low risk disease with a likelihood of favorable pathology threshold greater than 75% are at very low risk for adverse pathology, whereas those with a likelihood of favorable pathology of 75% or less are at high risk. This likelihood of favorable pathology threshold is greater than 69% for men with low volume intermediate risk disease. These results should help clinicians use Genomic Prostate Score information when making decisions regarding active surveillance or intervention for prostate cancer.