Article ID Journal Published Year Pages File Type
4278657 The American Journal of Surgery 2014 10 Pages PDF
Abstract

BackgroundIt remains controversial how preoperative biliary drainage affects occurrence of severe complications after pancreaticoduodenectomy (PD).MethodsOne hundred twenty-seven patients (60 external drainage and 67 internal drainage) required biliary drainage before PD were retrospectively reviewed.ResultsPreoperative cholangitis in internal drainage group (22.4%) occurred significantly more often than in external drainage group (1.7%; P < .001). The incidence of severe complications (grade III or more) was significantly higher in patients with cholangitis (62.5%) than in those without it (25.2%; P = .002). The incidence of delayed gastric emptying was significantly higher in patients with cholangitis (31.2%) than in those without it (5.4%; P = .001). A multivariate logistic regression analysis revealed that preoperative cholangitis (odds ratio 4.61, 95% confidence interval 1.3 to 16.5; P = .019) was the independent risk factor for severe complications after PD.ConclusionsPreoperative cholangitis during biliary drainage significantly increases incidence of severe complications after PD.

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