Collagen hemostat significantly reduces time to hemostasis compared with cellulose: COBBANA, a single-center, randomized trial

BackgroundThis single-center, randomized trial compares the hemostatic effectiveness of microfibrillar collagen and oxidized cellulose in arterial bypass surgery.MethodsIn patients undergoing arterial bypass surgery, 2 hemostats, microfibrillar collagen and oxidized cellulose, were randomly used to achieve hemostasis. The primary endpoint was the time to hemostasis. The secondary endpoints were the complication rate, mortality, number of hemostats required, handling, and adhesion.ResultsCollagen achieved hemostasis significantly faster than cellulose, with considerably less hemostats. In addition, its ease of use was rated substantially better.ConclusionIn arterial bypass surgery, microfibrillar collagen is more effective than oxidized cellulose in achieving hemostasis.