Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4280401 | The American Journal of Surgery | 2009 | 5 Pages |
BackgroundOptimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients.MethodsNinety-three (30%) of 311 patients with ILC received NAC. We examined margin status, residual disease after re-excision, and clinical outcomes.ResultsMargin positivity rates after the final operative procedure were similar between the NAC and surgery-first group (P > .05). The proportion of patients, stratified by margin status, who were taken back for re-excision was not different between the 2 groups, and, similarly, there were no differences in frequency of residual disease (all P > .05). At a median follow-up of 3.1 years, 1 patient in the NAC group and 2 in the surgery-first group developed LR (P = 1.0).ConclusionsPatients with ILC who have undergone NAC and have margins >1 mm have a low probability of residual disease and LR.