Article ID Journal Published Year Pages File Type
4294927 Journal of the American College of Surgeons 2007 12 Pages PDF
Abstract

BackgroundBefore extended hepatectomy of five or more segments, the remnant liver volume (RLV) is usually calculated as a ratio of RLV to total liver volume (RLV-TLV) and must be > 20% to 25%. This method can lead to compare parts of normal liver parenchyma to others compromised by biliary or vascular obstruction or by portal vein embolization. Extrapolating from living-donor liver transplantation, we hypothesized that RLV to body weight ratio (RLV-BWR) could accurately assess the functional limit of hepatectomy.Study designFrom September 2000 to December 2004, volumetric measurements of RLV using computed tomography were obtained before right-extended hepatectomy in 31 patients. RLV-BWR of 0.5% as a critical point for patient course was compared with stratification by RLV-TLV (≤ 25% or > 25% and ≤ 20% or > 20%).ResultsThree-month morbidity and mortality were not significantly different between groups RLV-TLV ≤ and > 25% and between groups RLV-TLV ≤ and > 20%, but increased significantly in group RLV-BWR ≤ 0.5% compared with group RLV-BWR > 0.5% (p = 0.038 and p = 0.019, respectively) with an non-significant increase in death from liver failure (p = 0.077).ConclusionsRLV-BWR was more specific than RLV-TLV in predicting postoperative course after extended hepatectomy. Patients with an anticipated RLV ≤ 0.5% of body weight are at considerable risk for hepatic dysfunction and postoperative mortality.

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