Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4299511 | Journal of Surgical Research | 2016 | 5 Pages |
Abstract
The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.
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Authors
Michael A. Zimmerman, Jennifer Schiller, Joohyun Kim, Alicia Martin, Motaz Selim, Trevor L. Nydam, David Cronin II, Johnny C. Hong,