Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4308129 | Surgery | 2012 | 5 Pages |
Abstract
One major barrier in the development of pancreas cancer therapeutics is the selective delivery of the drugs to their cellular targets. We have previously developed several sigma-2 ligands and reported the discovery of a component of the receptor for these ligands. Several sigma-2 ligands have been shown to trigger apoptosis in pancreas cancer cells. More importantly, sigma-2 ligands are internalized rapidly by the cancer cells and are capable of delivering other small-molecule therapeutics. Here we review sigma-2 ligands and conjugates as a potential novel therapy suitable for investigation in patients with pancreatic cancer.
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Authors
John R. Hornick, Dirk Spitzer, Peter Goedegebuure, Robert H. Mach, William G. Hawkins,