Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4308865 | Surgery | 2010 | 13 Pages |
Abstract
The immunomodulatory effects of epinephrine on neutrophils remained unchanged irrespective of cardiopulmonary bypass and could contribute to the detrimental effects of epinephrine after heart surgery. The preoperative administration of nonselective β-blockers abolished the immunomodulatory effects of epinephrine in vitro and in patients, and it enhanced the immunocompetence of neutrophils in a context of increased catecholamine levels.
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Authors
Benedikt MD, Dirk MD, Michael PhD, Dieter MD, Bernhard MD,