Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4309450 | Surgery | 2008 | 6 Pages |
Abstract
HNF1α and HNF1β are important transcription factors for endogenous SGLT1 expression by cultured enterocytes. GATA-5 and CDX2 also regulate SGLT1 promoter activity and show cooperativity with the HNF1s. We, therefore, propose a multifactorial model for SGLT1 regulation, with interactions between HNF1, GATA-5, and CDX2 modulating intestinal glucose absorption.
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Authors
Anita BMedSci, BMBS, Adam T. MA, BMBCh, David B. PhD, Stanley W. MD, Ali MBBS,