Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4311535 | Surgical Clinics of North America | 2009 | 18 Pages |
Abstract
Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Its effects are mediated by C difficile toxins A and B. Recent outbreaks of severe colitis have been associated with a new strain of the bacterium that produces large amounts of the toxins. Although oral metronidazole and oral vancomycin can be used to treat C difficile–associated disease, intraluminal vancomycin is preferable for more severe C difficile colitis. Early surgical intervention can improve outcomes with fulminant colitis, although overall mortality remains high.
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Authors
Philip A. Efron, John E. Mazuski,