| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4311990 | Behavioural Brain Research | 2017 | 5 Pages |
•NIRS can be applied to investigate brain activity in non-human primates.•NIRS can be a useful tool for direct comparison between animals and humans.•The prefrontal cortex exhibits neural activity associated with visual categorization.
In biomedical research of brain dysfunction in psychiatric disorders, utilization of animal models is essential. However, translation of findings in animal models into the realm of human clinical conditions requires reliable biomarkers that are assessed with the methods mutually employed in animal models and human patients. Near-infrared spectroscopy (NIRS) is a functional neuroimaging technique that has now been widely utilized in human basic and clinical research. However, its application to animal models has been barely conducted. In this study, we developed the method to measure neural activity in the cortex of Japanese macaques using NIRS, and examined cortical responses to presentation of a set of visual stimuli that were categorized into four different groups (flower, monkey, snake, food). Prefrontal cortical (PFC) oxy- and deoxy-hemoglobin changes were found to reliably distinguish the categories of these visual stimuli. The results suggest that cortical activity measurement with NIRS in primates can be a valuable model for identifying biomarkers associated with psychiatric disorders.
