| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4312876 | Behavioural Brain Research | 2013 | 7 Pages |
Abstract
⺠Prepulse inhibition (PPI) was disrupted in pinealectomized (Px) and pinealectomized-plus-ovariectomized (Px + Ovx) rats. ⺠Chronic melatoin treatment reversed the impairments of PPI induced by Px or Px + Ovx. ⺠Novel object recognition and passive avoidance tests were not affected by chronic melatonin treatment. ⺠Melatonin increased the locomotor activity of Px and Px + Ovx rats, but reversed the locomotor hyperactivity caused by Ovx. ⺠Chronic melatonin treatment may be useful in the disorders characterized by PPI disruption.
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Authors
T. Uzbay, H. Parlakpinar, E. Akdag, T. Celik, G. Yararbas, G. Ulusoy, A. Acet, A. Kose, H. Kayir,