Article ID Journal Published Year Pages File Type
4313190 Behavioural Brain Research 2012 8 Pages PDF
Abstract
► Hippocampal injections of P301L tau virus vector impaired spatial memory in rats. ► Memory impairments became evident about 6 weeks post-transduction. ► Memory impairments persisted for 6 months post-transduction. ► Abnormal phosphorylated tau and NFTs were evident in the hippocampus.
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Related Topics
Life Sciences Neuroscience Behavioral Neuroscience
Preview
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats
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