Does the endogenous neurogenic response alter behavioral recovery following stroke?

In response to stroke, the adult brain has the remarkable ability to enhance the proliferation of new cells, which form new neurons in restricted regions. This review focuses on studies that have directly tested the hypothesis that neurogenesis contributes to post-stroke behavioral recovery. The translational potential of this area of research is critically assessed with respect to the selection of appropriate stroke models, subjects, neurogenic regions examined, behavioral tests used, and experimental timecourse. Building upon those studies that suggest an association between endogeneous neurogenesis and improved stroke recovery, we are nonetheless left with the challenge to demonstrate a causal link between neurogenesis and behavioral recovery using new technology.

► Ischemic stroke induces proliferation in the adult subventricular zone of the lateral ventricle. ► Adult-generated neurons are proposed to influence behavior such as cognition and mood. ► Sensorimotor, cognitive and mood related behavioral deficits occur following stroke. ► Enhancement of neurogenesis is associated with improved post-stroke behavior. ► Future challenge to demonstrate a causal link between neurogenesis and recovery.