| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4313255 | Behavioural Brain Research | 2011 | 14 Pages |
Abstract
⺠Systemic applications of a dopaminergic D1 receptor antagonist dose-dependently reduced spatial exploration and object exploration. ⺠Appetitive spatial learning performance was reduced by this antagonist and this effect was hippocampus-dependent. ⺠Non-spatial object recognition performance was impaired by this antagonist. ⺠In contrast to these systemic effects, injections into the prelimbic cortices reduced spatial and non-spatial memory without affecting exploration. ⺠The effects of systemic application on exploration were synergistically enhanced by an antagonist for mGlu5.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Bettina Clausen, Todd R. Schachtman, Louise T. Mark, Mette Reinholdt, Gert R.J. Christoffersen,