Article ID Journal Published Year Pages File Type
4313505 Behavioural Brain Research 2012 8 Pages PDF
Abstract
► BBG attenuated both mechanical allodynia and thermal hypersensitivity induced by CCI. ► P2X7R expression was increased in dorsal horn of spinal cord of CCI rats. ► Spinal P2X7R expression was highly restricted to microglia. ► Microglia activation was inhibited by blocking P2X7 receptor in CCI rats.
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Life Sciences Neuroscience Behavioral Neuroscience
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Spinal P2X7 receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model
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