Dopamine D1 receptor antagonism impairs extinction of cocaine-cue memories

Increasingly, research suggests a role for dopamine D1 receptors in the consolidation of extinction of both appetitive and aversive memories. However, a role for D1 receptors in extinction of memories involving drug reward has yet to be established. Here we show that post-retrieval, but not delayed, systemic administration of the D1 receptor antagonist SCH23390 results in prolonged extinction of cocaine conditioned place preference (CPP), suggesting a critical role for D1 receptors in the consolidation of extinction of cocaine-cue memories.

► The role of dopamine D1 receptors in extinction of cocaine-cue memories is unknown. ► Post-retrieval SCH23390 prolonged extinction of learned cocaine-conditioned place preference. ► SCH23390 effects on extinction occurred dose-dependently. ► SCH23390's effects on extinction were unrelated to locomotor activity. ► D1 receptors are necessary for consolidating extinction of cocaine-cue memories.