| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4313618 | Behavioural Brain Research | 2012 | 8 Pages |
Abstract
⺠Anticholinergic trihexyphenidyl restored long-term depression in Dyt1 ÎGAG mice. ⺠Trihexylphenidyl also reversed motor control deficit in dystonia mouse model. ⺠Striatal D2 receptors were expressed at lower quantities in Dyt1 ÎGAG mice. ⺠Ca2+ channel agonist FPL64176 only partially induced dystonic signs in mutant mice. ⺠Cholinergic tone is important in synaptic plasticity and motor control in dystonia.
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Authors
Mai T. Dang, Fumiaki Yokoi, Chad C. Cheetham, Jun Lu, Viet Vo, David M. Lovinger, Yuqing Li,