An analysis of nicotine conditioned place conditioning in early postweanling and adolescent rats neonatally treated with quinpirole

► Neonatal quinpirole treatment enhanced nicotine place conditioning in adolescent male and female rats in the three-chambered place conditioning task. ► Nicotine induced a preference for the drug-paired context using the place conditioning paradigm in younger animals that has previously been shown. ► Distinctive results, including sex differences, were discovered depending on whether the two- or three-chambered place conditioning apparatus was used, which drastically effects interpretation of the associative effects of nicotine.