| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4313911 | Behavioural Brain Research | 2010 | 4 Pages |
Abstract
Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
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Authors
Kristóf László, Krisztián Tóth, Erika Kertes, László Péczely, Tamás Ollmann, László Lénárd,