Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4313912 | Behavioural Brain Research | 2010 | 4 Pages |
Abstract
This study reports that peripheral administration of Nerve Growth Factor antibodies (ANA) affects behavior in aged female CD-1 mice. ANA increased the propensity of mice to stay and perform behaviors in the anxiogenic open arms of the maze, lowered pain sensitivity and reduced behavioral flexibility in a Morris water maze task, also reducing ChAT immunoreactivity in the basal forebrain. These findings support the hypothesis that topical eye application can represent an alternative route for delivering biologically active compounds into the brain allowing studying the role of NGF on brain cell function.
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Authors
Alessandra Berry, Luigi Aloe, Simona Rossi, Luca T. Bonsignore, Francesca Capone, Enrico Alleva, Francesca Cirulli,