Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4314040 | Behavioural Brain Research | 2011 | 4 Pages |
Abstract
The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus.
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Authors
Sei Higuchi, Makiko Ohji, Maiko Araki, Riyo Furuta, Mai Katsuki, Ryuji Yamaguchi, Yoshiharu Akitake, Kiyoshi Matsuyama, Keiichi Irie, Kenji Mishima, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara,